PUBLICATIONS & ABSTRACTS
- Clinical Validation StudiesExtending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancerApril 2019
Syed Z. Ali MD, et al.
Cancer CytopathologyIdentification of Hürthle Cell Cancers: Solving a Clinical Challenge with Genomic Sequencing and a Trio of Machine Learning AlgorithmsApril 2019
Yangyang Hao, et al.
BMC Systems BiologyPerformance of a Genomic Sequencing Classifier for the Preoperative Diagnosis of Cytologically Indeterminate Thyroid NodulesMay 23, 2018
Patel KN, Angell TE, Babiarz J, et al.
JAMA SurgABSTRACT: Clinical Validation of Improved Genomic Classifier for Cytologically Indeterminate Thyroid Nodules Using an NGS Platform and Machine Learning Algorithms in an Independent Prospective Multicenter Blinded Cohort Demonstrates Improved PerformanceJuly 30, 2017
Patel, Kepal N
WCTC 2017
Boston, MAPreoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology Alexander EK, et al.Aug 2012
Erik K. Alexander, M.D., et al.
The New England Journal of MedicineABSTRACT: Development and Validation of Classifiers to Enhance the Afirma Genomic Sequencing Classifier Performance Among Hürthle Cell SpecimensOctober 21, 2017
Duh, Quan-Yang
ATA 2017ABSTRACT: Clinical Validation of the Afirma Genomic Sequencing Classifier for Medullary Thyroid CancerOctober 21, 2017
Randolph, Gregory
ATA 2017ABSTRACT: Clinical Validation of the Afirma Genomic Sequencing BRAF V600E ClassifierOctober 19, 2017
Angell, Trevor E.
ATA 2017ABSTRACT: Clinical Validation of the Afirma Genomic Sequencing Parathyroid ClassifierFri, October 20, 2017
Sosa, Julie Ann
ATA 2017ABSTRACT: Community Endocrine Surgical Experience with False Negative Afirma GEC ResultsJuly 29, 2017
Harrell, R. Mack
WCTC 2017
Boston, MAA Genomic Alternative to Preoperatively Identify Medullary Thyroid Cancer in Thyroid Nodules with Indeterminate CytologyMarch 4, 2016
Richard T. Kloos, et al.
ThyroidDoes Addition of BRAF V600E Mutation Testing Modify Sensitivity or Specificity of the Afirma Gene Expression Classifier in Cytologically Indeterminate Thyroid Nodules?March 2013
Richard T. Kloos, et al.
The Journal of Clinical Endocrinology & MetabolismA Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and HistopathologyMarch 31, 2011
Chung-Che Charles Wang, et al.
ThyroidClinical Utility StudiesORAL ABSTRACT: Identification of Novel and Rare Receptor Tyrosine Kinase Fusions in Thyroid Fine Needle AspiratesMarch 2020
Lori J. Wirth, et al.
Endocrine Society 2020 Annual Meeting (canceled due COVID-19)
San Francisco, CAABSTRACT: Positive Predictive Value of TP53 Variants in Bethesda III/IV Thyroid Fine-Needle AspiratesMarch 2020
Masha J. Livhits, et al.
Endocrine Society 2020 Annual Meeting (canceled due COVID-19)
San Francisco, CAAfirma Gene Sequencing Classifier compared to Gene Expression Classifier in Indeterminate Thyroid NodulesJune 2019
Mayumi Endo, et al.
ThyroidIndependent Comparison of the Afirma Genomic Sequencing Classifier and Gene Expression Classifier for Cytologically Indeterminate Thyroid Nodules (B&W)May 2019
Trevor E. Angell, et al.
ThyroidABSTRACT: The Genomic Landscape of Preoperative FNAs positive for the Afirma GSC Medullary Thyroid Cancer ClassifierMarch 2019
Steve Waguespack, et al.
Endocrine Society 2019 Annual Meeting
New Orleans, LAStatistical Comparison of Afirma GSC and Afirma GEC Outcomes in a Community Endocrine Surgical Practice: Early FindingsNovember 2018
R. Mack Harrell, et al.
Endocrine PracticeABSTRACT: Experience with the Genomic Sequencing Classifier in >100 Cytologically Indeterminate Thyroid NodulesOctober 4, 2018
Mayumi Endo, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: An Independent Performance Comparison of the Afirma Genomic Sequencing Classifier (GSC) and Gene Expression Classifier (GEC) for Cytologically Indeterminate Thyroid NodulesOctober 5, 2018
Ellen Marqusee, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: Xpression Atlas Variants and Fusions Found Among 4,742 Thyroid NodulesOctober 6, 2018
Allan Golding, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: Xpression Atlas Findings in the Genomic Sequencing Classifier (GSC) Clinical Validation CohortOctober 6, 2018
Trevor Angell, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: Performance of Afirma Genomic Sequencing Classifier: The Initial Cleveland Clinic ExperienceOctober 6, 2018
Vicente San Martin, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: Automatic Identification of Hürthle Cells and Hürthle Neoplasia by Two Classifiers that Coordinate with the Core Afirma GSC ClassifierOctober 6, 2018
Christian Nasr, et al.
American Thyroid Association (ATA) 2018 Annual Meeting
Washington, DCABSTRACT: Early Experience of Gene Sequencing Classifier Compared to Gene Expression ClassifierMay 19, 2018
Mayumi Endo, et al.
American Association of Clinical Endocrinologists (AACE) Annual Meeting
Boston, MAABSTRACT: Afirma GSC: Early Endocrine Surgical Practice PerformanceMay 19, 2018
R. Mack Harrell, et al.
American Association of Clinical Endocrinologists (AACE) Annual Meeting
Boston, MAABSTRACT: Afirma Genomic Sequencing Classifier Experience among the First 5478 Consecutive Samples from Cytologically Indeterminate Thyroid NodulesMarch 17, 2018
Michael Shanik, et al.
Endocrine Society Annual Meeting
Chicago, ILABSTRACT: Reduced Surgery Through Afirma GEC: Impact to Date and Potential for the FutureMay 5, 2017
Harrell, R.M, et al.
AACE 2017 Congress
Austin, TXABSTRACT: Five Year Experience with Afirma Gene Expression Classifier (GEC) at a Southern California Teaching HospitalSeptember 24, 2016
H.M. Huribal, et al.
86th Annual Meeting of the American Thyroid Association
Denver, COABSTRACT: The First Canadian Experience with the Afirma Gene Expression Classifier TestSeptember 22, 2016
E. Kay-Rivest, et al.
86th Annual Meeting of the American Thyroid Association
Denver, COABSTRACT: Systematic Review of Clinical Utility and Longer-Term Follow-up of Afirma GEC TestingApril 2, 2016
Richard T Kloos, et al.
Endo Society 98th Annual Meeting
Boston, MAImpact of a gene expression classifier on the long-term management of patients with cytologically indeterminate thyroid nodulesMarch 31, 2016
Singer, J. et al.
Current Medical Research & OpinionHas Afirma Gene Expression Classifier Testing Refined the Indeterminate Thyroid Category in Cytology?February 27, 2016
Yang S, et al.
Cancer CytopathologyLong-Term Non-Operative Rate of Thyroid Nodules With Benign Results on the Afirma Gene Expression ClassifierJanuary 31, 2016
Sipos JA, et al.
Endocrine Practice (In press)Afirma Benign Thyroid Nodules Show Similar Growth to Cytologically Benign Nodules During Follow UpOctober 1, 2015
Angell TE, et al.
The Journal of Clinical Endocrinology & MetabolismOutcome of Thyroid Gene Expression Classifier Testing in Clinical PracticeOctober 1, 2015
Witt RL, et al.
The Laryngoscope (Link to abstract only)Multicenter Clinical Experience with the Afirma Gene Expression ClassifierOctober 31, 2013
Alexander EK, et al
The Journal of Clinical Endocrinology & Metabolism (Link to abstract only)Does Addition of BRAF V600E Mutation Testing Modify Sensitivity or Specificity of the Afirma Gene Expression Classifier in Cytologically Indeterminate Thyroid Nodules?March 30, 2013
Kloos RT, et al.
The Journal of Clinical Endocrinology & Metabolism (Link to abstract only)Use of the Afirma® Gene Expression Classifier for Preoperative Identification of Benign Thyroid Nodules with Indeterminate Fine Needle Aspiration CytopathologyMarch 1, 2013
Syed AZ, et al.
PLOSThe Impact of Benign Gene Expression Classifier Test Results on the Endocrinologist–Patient Decision to Operate on Patients with Thyroid Nodules with Indeterminate Fine-Needle Aspiration CytopathologyOctober 30, 2012
Duick D et al.
ThyroidCost-Effectiveness of a Novel Molecular Test for Cytologically Indeterminate Thyroid NodulesNovember 1, 2011
Li H, et al.
The Journal of Clinical Endocrinology & Metabolism (Link to abstract only)A Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and HistopathologyMarch 31, 2011
Wang CC, et al.
ThyroidMolecular Classification of Thyroid Nodules Using High-Dimensionality Genomic DataDecember 1, 2010
Chudova D, et al.
The Journal of Clinical Endocrinology & Metabolism (Link to abstract only)Analytical Validation StudiesABSTRACT: Analytical Performance of Afirma GSC: A Genomic Sequencing Classifier for Cytology-Indeterminate Thyroid Nodule FNA SpecimensFri, October 20, 2017
Hu, Zhanzhi, et al.
ATA 2017Analytical Performance Verification of a Molecular Diagnostic for Cytology-Indeterminate Thyroid NodulesOctober 31, 2012
Walsh, et al.
The Journal of Clinical Endocrinology & MetabolismNotable TopicsPositive Predictive Value of NTRK, RET, BRAF, and ALK Fusions in Bethesda III/IV Thyroid Fine-Needle AspiratesNovember 2019
Stack B, et al.
American Thyroid Association (ATA) Annual Meeting
Chicago, ILIdentification of Rare, Canonically Mutually Exclusive Variants in Thyroid FNAsNovember 2019
Haugen B, et al.
American Thyroid Association (ATA) Annual Meeting
Chicago, ILNTRK, RET, BRAF, and ALK Fusions in Thyroid Fine-Needle Aspirates (FNAs)November 2019
Hu M, et al.
American Thyroid Association (ATA) Annual Meeting
Chicago, ILABSTRACT: Genomic Landscape of FNAs Positive for Medullary Thyroid Cancer and Potential Impact on Systemic TherapyJune 1, 2019
Lori J. Wirth, et al.
American Society of Clinical Oncology (ASCO) 2019 Annual Meeting
Chicago, ILABSTRACT: Detecting Expressed Variants and Fusions in RNA-Seq Data from Thyroid FNAsMay 19, 2018
Peter M Sadow, et al.
American Association of Clinical Endocrinologists (AACE) Annual Meeting
Boston, MAABSTRACT: The Mutational Landscape of 774 Variants and 132 Fusions in 513 Genes Measured in Thyroid FNAs from a Multi-Center, Blinded CohortMarch 18, 2018
Joshua E. Babiarz, et al.
Endocrine Society Annual Meeting
Chicago, ILABSTRACT: Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features and Indeterminate Cytology Are Afirma GEC Suspicious Which Facilitates Surgical TreatmentApril 1, 2017
Peter M Sadow, MD, PhD, et al.
The Endocrine Society 99th Annual Meeting and Expo
Orlando, FLABSTRACT: Systematic Review of the Positive Predictive Value of RAS Mutations in Cytologically Indeterminate Thyroid NodulesMay 28, 2016
Richard Kloos, MD, et al.
AACE 25th Annual Scientific and Clinical Congress
Orlando, FLABSTRACT: Detection of Malignancy in Thyroid Carcinoma Samples through Targeted DNA SequencingMay 27, 2016
Travers, K, et al.
AACE 25th Annual Scientific and Clinical Congress
Orlando, FLA Prospective Assessment Defining the Limitations of Thyroid Nodule Pathologic EvaluationOctober 1, 2013
Cibas ES, et. al.
Annals of Internal Medicine